Diabetic Foot Treatment (Heberprot-P)
A growth factor therapy that helps heal diabetic foot ulcers and lower the risk of amputation.
Diabetic Foot Treatment (Heberprot-P)
A growth factor therapy that helps heal diabetic foot ulcers and lower the risk of amputation.
Read our in-depth guide: Diabetic Foot Ulcer
Symptoms, diagnosis, stages, Cuban treatment approach, eligibility & costs
Heberprot-P is a unique Cuban biotechnology product. It contains a recombinant (lab-made) human Epidermal Growth Factor (hEGF) — a protein that helps skin and tissue cells grow and heal. It is given by injection directly into the edges of complex diabetic foot ulcers (open wounds on the feet that are hard to heal). Developed by the Center for Genetic Engineering and Biotechnology (CIGB) in Havana, it offers a treatment option for wounds that have not responded to standard care.
Your Patient Journey
What to expect before, during, and after your treatment in Cuba.
- Step 1
Before You Arrive
Send your medical records for review. Our coordination team confirms eligibility, builds a personalized plan, and assists with visa and travel arrangements.
- Free remote medical records evaluation
- Visa and travel coordination
- Personalized treatment plan
- Step 2
During Treatment
Receive your treatment at one of our partner centers in Havana. A dedicated coordinator supports you at every appointment and procedure.
- Admission to partner center
- Specialist consultations and procedures
- On-site coordinator support
- Step 3
Aftercare & Recovery
Continue your recovery with a structured discharge plan, follow-up coordination, and remote check-ins with your Cuban medical team once you return home.
- Structured discharge and care plan
- Follow-up appointment scheduling
- Remote check-ins with your team
Outcomes & Recovery
An overview of documented outcomes and what to expect during and after treatment. Individual results vary and are confirmed during your personalized evaluation.
Success Rates & Experience
Typical Recovery Timeline
Assessment
Wound grading (Wagner/UT), vascular and neurological evaluation confirm suitability.
Injection therapy
Intralesional Heberprot-P three times weekly, combined with debridement, offloading and infection control.
Wound closure & follow-up
Monitoring until closure, with glycemic control and a home-care plan to prevent recurrence.
These figures reflect clinical experience and published studies. Individual results vary and are confirmed during a personalized medical evaluation.
Cuban Biotech vs. Standard International Care
A side-by-side look at what makes this treatment distinctive compared with conventional options abroad.
| Aspect | SMC Salud (Cuba) | Standard International Care |
|---|---|---|
| Treatment approach | Intralesional recombinant human EGF (Heberprot-P) injected directly into the wound edges. | Standard wound care: debridement, dressings, offloading, and antibiotics. |
| Mechanism of action | Delivers growth factor to the wound site to stimulate cellular proliferation and tissue regeneration. | Manages symptoms and infection but offers no pro-healing biological agent. |
| Amputation risk | Developed specifically to reduce amputation in ulcers that fail conventional care. | High amputation rates once standard wound care has failed. |
| Healing reach | Can heal complex ulcers (Wagner grade 2–4) that are unresponsive to standard therapy. | Limited options for non-healing wounds. |
| Registration & scale | Registered in 26+ countries and used in thousands of patients worldwide. | No comparable growth-factor product widely available internationally. |
| Administration | Specialist-administered 3× per week for up to 8 weeks, with full diabetes management. | Variable outpatient wound-clinic visits with no standardized biological protocol. |
Treatment approach
SMC Salud (Cuba)
Intralesional recombinant human EGF (Heberprot-P) injected directly into the wound edges.
Standard International Care
Standard wound care: debridement, dressings, offloading, and antibiotics.
Mechanism of action
SMC Salud (Cuba)
Delivers growth factor to the wound site to stimulate cellular proliferation and tissue regeneration.
Standard International Care
Manages symptoms and infection but offers no pro-healing biological agent.
Amputation risk
SMC Salud (Cuba)
Developed specifically to reduce amputation in ulcers that fail conventional care.
Standard International Care
High amputation rates once standard wound care has failed.
Healing reach
SMC Salud (Cuba)
Can heal complex ulcers (Wagner grade 2–4) that are unresponsive to standard therapy.
Standard International Care
Limited options for non-healing wounds.
Registration & scale
SMC Salud (Cuba)
Registered in 26+ countries and used in thousands of patients worldwide.
Standard International Care
No comparable growth-factor product widely available internationally.
Administration
SMC Salud (Cuba)
Specialist-administered 3× per week for up to 8 weeks, with full diabetes management.
Standard International Care
Variable outpatient wound-clinic visits with no standardized biological protocol.
Recommended Cuban Products
Cuban medications and supplements related to this treatment, available through our pharmacy service.
Heberprot-P® (hEGF)
Lyophilized vial 75 µg · case of 6 bulbs
Complex diabetic foot ulcers (Wagner grade 2–4)
Recombinant human Epidermal Growth Factor developed by CIGB. Administered by intralesional injection to stimulate granulation tissue and skin regeneration, reducing amputation risk. Hospital use only. Registered in 26+ countries.
Hebermin® (Topical hEGF)
Cream · 30 g or 120 g polyethylene bottle
Burns, surgical wounds, radiation injuries, dermal ulcers
Recombinant human epidermal growth factor cream by CIGB. Accelerates healing of superficial and deep burns and scars, and supports tissue regeneration in surgical procedures.
Biopla® Dietary Supplement
Capsules · 40-capsule flask (500 mg each)
Osteoporosis · bone fractures · anemia · post-op recovery · burns · wound healing · physical effort
Protein-mineral concentrate extracted from human placenta (HISPLACEN). Each 500 mg capsule contains digestible protein 369.5 mg, phosphorus, calcium, iron, zinc, copper, vitamin B2, plus essential amino acids (methionine, leucine, lysine, valine, serine, phenylalanine, threonine, tyrosine). No adverse effects. Take 1 capsule twice daily with water or fruit juice after meals.
These products are shown for informational purposes and may be prescribed or purchased through SMC Salud's pharmacy service. Prescription items (Rx) require a valid medical prescription; vaccines and biologics are administered under medical supervision only. Always consult your treating physician.
Frequently Asked Questions
Find answers about the medical procedure and the full range of patient support services we provide for this treatment.
About the Procedure — Diabetic Foot Treatment (Heberprot-P)
Patient Support Services
Cuban Biotech Therapies
Medically Reviewed
SMC Salud Medical Review Board
Board-certified physicians and specialists in oncology, neurology, dermatology, and endocrinology
Last reviewed: January 15, 2025
This content has been medically reviewed by qualified physicians and follows SMC Salud's editorial policy for health information. Medical content is for informational purposes and does not replace professional medical advice.
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Treatment suitability depends on specialist evaluation. Individual treatment plans apply.