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What is Melagenin Plus®?

Melagenin Plus® is a topical medication derived from human placenta, developed at Cuba's Placental Histotherapy Center. It contains a lipoprotein fraction that stimulates melanocyte proliferation and melanin production, aiming to repigment vitiligo-affected skin.

Is Melagenin Plus® treatment painful?

No, the treatment is painless and non-invasive. It involves daily application of the topical medication to affected areas followed by controlled sun exposure or phototherapy.

How long does vitiligo treatment take?

Initial treatment cycles typically last 2–4 weeks in Cuba. Some patients may benefit from extended or multiple cycles. The dermatology team monitors progress and recommends the optimal treatment duration based on individual response.

Will vitiligo come back after treatment?

Vitiligo is a chronic condition and repigmentation results vary by individual. Some patients achieve significant repigmentation while others may have partial response. Maintenance strategies and follow-up care are discussed with each patient.

Is Melagenin Plus® available outside Cuba?

Melagenin Plus® is a Cuban-developed therapy available through Cuba's specialized dermatology centers. It is not widely available in other countries, which is why international patients travel to Cuba for treatment.

Vitiligo — Full GuideDermatology

Diagnosing Vitiligo

Vitiligo is typically diagnosed through clinical examination by a dermatologist. The diagnosis is based on the characteristic appearance of depigmented patches. A Wood's lamp (ultraviolet light) examination can help highlight affected areas, especially in lighter-skinned individuals.

Additional tests may include blood work to check for associated autoimmune conditions (thyroid function, autoimmune markers), skin biopsy in uncertain cases, and assessment of disease activity to determine whether the vitiligo is stable or actively progressing.

Cuban dermatology specialists perform a thorough assessment to determine the type, extent, and activity of vitiligo, which guides the treatment approach and helps set realistic expectations for repigmentation.

Previous SectionVitiligo Symptoms and Types Next Section Melagenin Plus®: Cuba's Placental Histotherapy for Vitiligo

All Sections — Vitiligo

1.Vitiligo and Cuba's Unique Treatment Approach 2.Vitiligo Symptoms and Types 3.Diagnosing Vitiligo 4.Melagenin Plus®: Cuba's Placental Histotherapy for Vitiligo 5.Eligibility for Vitiligo Treatment in Cuba 6.Travel and Treatment Costs for Vitiligo Patients

Medically Reviewed

Dr. Ana Fernández

MD, Dermatology — Havana Dermatology Center

Last reviewed: July 3, 2026

Medical References

[1]Cuba's Placental Histotherapy Center. Melagenin Plus® Clinical Documentation.
[2]American Academy of Dermatology. Vitiligo: Diagnosis and Treatment.
[3]Vitiligo Research Foundation. Vitiligo Facts and Statistics.

This content has been medically reviewed by qualified physicians and follows SMC Salud's editorial policy for health information. Medical content is for informational purposes and does not replace professional medical advice.

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