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What is Melagenin Plus®?

Melagenin Plus® is a topical medication derived from human placenta, developed at Cuba's Placental Histotherapy Center. It contains a lipoprotein fraction that stimulates melanocyte proliferation and melanin production, aiming to repigment vitiligo-affected skin.

Is Melagenin Plus® treatment painful?

No, the treatment is painless and non-invasive. It involves daily application of the topical medication to affected areas followed by controlled sun exposure or phototherapy.

How long does vitiligo treatment take?

Initial treatment cycles typically last 2–4 weeks in Cuba. Some patients may benefit from extended or multiple cycles. The dermatology team monitors progress and recommends the optimal treatment duration based on individual response.

Will vitiligo come back after treatment?

Vitiligo is a chronic condition and repigmentation results vary by individual. Some patients achieve significant repigmentation while others may have partial response. Maintenance strategies and follow-up care are discussed with each patient.

Is Melagenin Plus® available outside Cuba?

Melagenin Plus® is a Cuban-developed therapy available through Cuba's specialized dermatology centers. It is not widely available in other countries, which is why international patients travel to Cuba for treatment.

Vitiligo — Full GuideDermatology

Melagenin Plus®: Cuba's Placental Histotherapy for Vitiligo

Melagenin Plus® is a topical medication developed at Cuba's Placental Histotherapy Center. It is derived from human placenta and contains a lipoprotein fraction that stimulates melanocyte proliferation and melanin production. The treatment aims to repigment affected skin areas.

Treatment involves daily application of Melagenin Plus® to affected areas, followed by controlled exposure to sunlight or phototherapy. The treatment is painless and non-invasive, making it suitable for patients of all ages and skin types. Treatment cycles typically last several weeks.

Cuba's approach may also include Coriodermina® for related skin conditions and other placental histotherapy products. The dermatology team monitors progress throughout treatment and adjusts the protocol as needed. Best results are typically seen in patients with stable vitiligo affecting limited body areas.

Previous SectionDiagnosing Vitiligo Next Section Eligibility for Vitiligo Treatment in Cuba

All Sections — Vitiligo

1.Vitiligo and Cuba's Unique Treatment Approach 2.Vitiligo Symptoms and Types 3.Diagnosing Vitiligo 4.Melagenin Plus®: Cuba's Placental Histotherapy for Vitiligo 5.Eligibility for Vitiligo Treatment in Cuba 6.Travel and Treatment Costs for Vitiligo Patients

Medically Reviewed

Dr. Ana Fernández

MD, Dermatology — Havana Dermatology Center

Last reviewed: July 3, 2026

Medical References

[1]Cuba's Placental Histotherapy Center. Melagenin Plus® Clinical Documentation.
[2]American Academy of Dermatology. Vitiligo: Diagnosis and Treatment.
[3]Vitiligo Research Foundation. Vitiligo Facts and Statistics.

This content has been medically reviewed by qualified physicians and follows SMC Salud's editorial policy for health information. Medical content is for informational purposes and does not replace professional medical advice.

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